MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma.
作者： Yang Ni , Long Meng , Liguang Wang , Wei Dong , Hongchang Shen
DOI: 10.1016/J.GENE.2012.12.031
关键词:
摘要: Esophageal cancer is one of the most common cancers worldwide with a poor prognosis. MicroRNAs(miRNAs) are class naturally occurring small noncoding RNAs and play an important role in initiation development. In this study, we demonstrate that expression levels miR-143 miR-145 were significantly decreased ESCC tissues comparison adjacent normal esophageal squamous tissues(NESTs). Furthermore, inverse correlation between tumor invasion depth lymph node metastasis was observed. The enforced induced growth suppression apoptosis cells. Rescue suppressed cells migration capabilities. Moreover, show functions mediated at least part by inhibition extracellular signal regulated kinase-5(ERK-5) activity. These results prove may act as suppressor ESCC.
sci-hub.se 参考文章(49)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Catherine Gratas, Hiroko Ohgaki, Pierre Hainaut, Philippe Taniere, Christoph Barnas, Yasuo Tohma, Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Cancer Research. ,vol. 58, pp. 2057- 2062 ,(1998)
Shuomin Zhu, Hailong Wu, Fangting Wu, Daotai Nie, Shijie Sheng, Yin-Yuan Mo, MicroRNA-21 targets tumor suppressor genes in invasion and metastasis Cell Research. ,vol. 18, pp. 350- 359 ,(2008) , 10.1038/CR.2008.24
Takeshi Takagi, Akio Iio, Yoshihito Nakagawa, Tomoki Naoe, Nobuhiko Tanigawa, Yukihiro Akao, Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology. ,vol. 77, pp. 12- 21 ,(2009) , 10.1159/000218166
M Pichler, E Winter, M Stotz, K Eberhard, H Samonigg, S Lax, G Hoefler, Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer British Journal of Cancer. ,vol. 106, pp. 1826- 1832 ,(2012) , 10.1038/BJC.2012.175
Yuli C. Chang, Kun-Tu Yeh, Ta-Chih Liu, Jan-Gowth Chang, Molecular cytogenetic characterization of esophageal cancer detected by comparative genomic hybridization Journal of Clinical Laboratory Analysis. ,vol. 24, pp. 167- 174 ,(2010) , 10.1002/JCLA.20385
Masayuki Kano, Naohiko Seki, Naoko Kikkawa, Lisa Fujimura, Isamu Hoshino, Yasunori Akutsu, Takeshi Chiyomaru, Hideki Enokida, Masayuki Nakagawa, Hisahiro Matsubara, miR‐145, miR‐133a and miR‐133b: Tumor‐suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma International Journal of Cancer. ,vol. 127, pp. 2804- 2814 ,(2010) , 10.1002/IJC.25284
Cyrielle Clapé, Vanessa Fritz, Corinne Henriquet, Florence Apparailly, Pedro Luis Fernandez, François Iborra, Christophe Avancès, Martin Villalba, Stéphane Culine, Lluis Fajas, miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice PLoS ONE. ,vol. 4, pp. e7542- ,(2009) , 10.1371/JOURNAL.PONE.0007542
Yukihiro Akao, Yoshihito Nakagawa, Akio Iio, Tomoki Naoe, Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells Leukemia Research. ,vol. 33, pp. 1530- 1538 ,(2009) , 10.1016/J.LEUKRES.2009.04.019
Kimberly R. Cordes, Neil T. Sheehy, Mark P. White, Emily C. Berry, Sarah U. Morton, Alecia N. Muth, Ting-Hein Lee, Joseph M. Miano, Kathryn N. Ivey, Deepak Srivastava, miR-145 and miR-143 regulate smooth muscle cell fate and plasticity Nature. ,vol. 460, pp. 705- 710 ,(2009) , 10.1038/NATURE08195