Selenoprotein P and Selenium Distribution in Mammals

摘要: Selenoprotein P (Sepp) is a remarkable selenoprotein. Among all mammalian selenoproteins, it the only one containing more than selenocysteine, and ten in humans. Sepp plasma protein mainly originating liver, but also expressed other organs, notably brain, placenta, lactating mamma. The main function of transport selenium (Se) to target tissues. Hepatocytes thus convert nutritional selenocompounds into for distribution, mother’s milk contains as an essential gift offspring. fact that about 25 % selenoprotein mRNAs hepatocytes code alone highlights its central position body’s Se homeostasis. Selenium status individual reflected by serum concentration Sepp. Endocytic receptors lipoprotein receptor-related (Lrp) family participate targeting cell-specific uptake retention. A Sepp-cycle exists testes, kidney appears preserve tissue during times poor supply, explaining long known hierarchical differences tissue-specific retention deficiency. Individual genotype may modulate these processes exerting influence on relative expression levels response intake, risk Se-dependent diseases.