A comparative protein profiling of lymphocytes from blood of patients with chronic lymphoid leukemia by high-resolution mass-spectrometry in search of new markers for heterogeneity and disease prognosis
作者： Yu E Glazyrin , MA Komarova , VI Bakhtina , MV Silacheva , IV Demko
DOI: 10.1134/S1061934816130062
关键词:
摘要: To find new markers of chronic lymphoid leukemia heterogeneity, a comparison the proteomic profiles pathologic and healthy lymphocytes from blood was carried out by high-resolution mass spectrometry label-free quantitative analysis. A list most typical proteins for two groups obtained. The differences in within group, which were consistent with heterogeneity clinical background, found. Two subsets area cells formed using statistical analysis; characteristic each subset
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