Differential effects of thalidomide on angiogenesis and tumor growth in mice.

摘要: Thalidomide, clinically used as an antiinflammatory and antitumoral drug, inhibited sponge-induced angiogenesis when administered systemically (100 mg/kg−1) in mice. However, it failed to inhibit solid Ehrlich tumor the same mouse strain. We have functional, biochemical histological parameters assess neovascularization fibrovascular tissue infiltration of mice sponge granuloma. The growth detected by development blood flow hemoglobin content extracted from implants showed that thalidomide formation 40%. functional correlated well with study. Thalidomide had no inhibitory effect tumor. detection this selective action using animal strain bearing two different processes, supports hypothesis rather than species specificity, is specific. This approach may be identify specificity other therapeutic agents against distinct angiogenesis-dependent diseases.