Differential effects of antiangiogenic compounds in neovascularization, leukocyte recruitment, VEGF production, and tumor growth in mice.

摘要: Angiogenesis and inflammation play critical roles in tumor growth. Using an vivo model, we report that thalidomide (100 mg kg− 1 day− 1) or clotrimazole (120 1), inhibit blood vessel formation (determined by hemoglobin content), leukocyte recruitment [myeloperoxidase (MPO) activity; N-acetylglucosaminidase (NAG) activity], vascular endothelial growth factor production. Inhibition of angiogenesis ranged from 35% to 65%. Clotrimazole was the most potent antiangiogenic compound agent capable inhibiting Thalidomide able reduce inflammatory reaction (MPO NAG activities) 50% 70%, but unable delay development. These results suggest for this type solid degree neovascularization, rather than inhibition cell recruitment, is a determinant As contribution cancer progression vary markedly among different types, it may be re...