MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.
作者： Feng Zhao , Liu-Hua Zhou , Yu-Zheng Ge , Wen-Wen Ping , Xin Wu
DOI: 10.1002/JCP.27288
关键词:
摘要: MicroRNAs (miRNAs), a group of small noncoding RNAs, are widely involved in the regulation gene expression via binding to complementary sequences at 3'-untranslated regions (3'-UTRs) target messenger RNAs. Recently, downregulation miR-133b has been detected various human malignancies. Here, potential biological role bladder cancer (BC) was investigated. In this study, we found markedly downregulated BC tissues and cell lines (5637 T24), correlated with poor overall survival. Notably, transgelin 2 (TAGLN2) be upregulated BC, overexpression TAGLN2 also significantly increased risks advanced TMN stage. We further identified that upregulation inhibited glucose uptake, invasion, angiogenesis, colony formation enhances gemcitabine chemosensitivity by targeting TAGLN2. Additionally, showed promoted proliferation cells, least partially through TAGLN2-mediated cycle pathway. Our results suggest novel miR-133b/TAGLN2/cell pathway axis controlling progression; molecular mechanism which may offer therapeutic target.
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