The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users.

摘要: Abstract Background Prior studies have separately examined the effects of dronabinol (oral THC) on cannabis withdrawal, cognitive performance, and acute smoked cannabis. A single study examining these clinically relevant domains would benefit continued evaluation as a potential medication for treatment use disorders. Methods Thirteen daily smokers completed within-subject crossover received 0, 30, 60 120 mg per day 5 consecutive days. Vital signs subjective ratings craving sleep were obtained daily; outcomes under active dose conditions compared to those placebo dosing. On 5th maintenance, participants comprehensive performance battery then five puffs evaluation. Each maintenance period occurred in counterbalanced order was separated by 9 days ad libitum use. Results Dronabinol dose-dependently attenuated withdrawal resulted few adverse side or decrements performance. Surprisingly, did not alter cannabis, but cannabis-induced increases heart rate doses. Conclusions Dronabinol's ability suppress may be therapeutically beneficial individuals trying stop The absence gross impairment this supports safety doses up 120 mg/day. Continued targeted clinical treatment, using an expanded range doses, is warranted.