Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT) side-effects in the treatment of depression

摘要: Electroconvulsive therapy (ECT) is an effective treatment for depression, but can have negative side effects including amnesia. The mechanisms of action underlying both the antidepressant and ECT are not well understood. An equivalent manipulation that conducted in experimental animals electroconvulsive seizure (ECS). Rodent studies provided valuable insights into potential ECT. However, relatively few investigated ECS animal models with a depression-relevant such as chronic stress. In present study, mice were first exposed to social stress (CSS) or control procedure 15 days followed by sham 10 days. Behavioral using auditory fear conditioning (learning) expression (memory) test treadmill-running fatigue test. Thereafter, immunohistochemistry was on brain material microglial marker Iba-1 cholinergic fibre ChAT. CSS did increase learning memory design; reduced expression. induced expected fatigue-like effect test; increased mice. inflammation hippocampus terms radiatum CA1 CA3. acetylcholine function indicated decreased ChAT several hippocampal sub-regions. Therefore, activity and, rather than reversing these effects, repeated regimen resulted impaired learning-memory, fatigue, expression, As such, current model does provide mechanism evidence pathophysiological might contribute important side-effects.