The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients
作者： Li-Bo Yang , Lin-Yong Sun , Yong Jiang , Ying Tang , Zhi-Hui Li
DOI: 10.1155/2015/642046
关键词:
摘要: The BRAF(V600E) mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies regions. However, the association between and clinicopathological features Chinese PTC patients unknown. A total of 543 with histologically confirmed were enrolled this study. For BRAF assay, target fragments amplified sequenced an ABI 3500 gene analyzer. In 170 samples (31.3%), was detected. bivariate analysis, showed bilaterality, tumor size, extrathyroidal invasion, lymph node metastases (LNM). multivariate positively related to only size (>1 cm) invasion. addition, analysis also that age diagnosis ( 1 cm) independent predictors for LNM. study, associated worse prognostic factors, including larger extending capsule or region; however, it not predictor
hindawi.com
core.ac.uk参考文章(56)
Yale D. Podnos, David Smith, Lawrence D. Wagman, Joshua D.I. Ellenhorn, The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer American Surgeon. ,vol. 71, pp. 731- 734 ,(2005) , 10.1177/000313480507100907
Bruce H. Haughey, Marci M. Lesperance, Valerie Lund, K. Thomas Robbins, John K. Niparko, J. Regan Thomas, [edited by] Paul W. Flint, Cummings Otolaryngology: Head and Neck Surgery ,(2004)
Carlo La Vecchia, Matteo Malvezzi, Cristina Bosetti, Werner Garavello, Paola Bertuccio, Fabio Levi, Eva Negri, Thyroid cancer mortality and incidence: A global overview International Journal of Cancer. ,vol. 136, pp. 2187- 2195 ,(2015) , 10.1002/IJC.29251
Sophie Scherl, Saral Mehra, Jason Clain, Laura L. Dos Reis, Mark Persky, Andrew Turk, Bruce Wenig, Hasan Husaini, Mark L. Urken, The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer? Thyroid. ,vol. 24, pp. 1282- 1288 ,(2014) , 10.1089/THY.2013.0600
Yasuhiro ITO, Hiroshi YOSHIDA, Rie MARUO, Shinji MORITA, Toru TAKANO, Mitsuyoshi HIROKAWA, Tomonori YABUTA, Mitsuhiro FUKUSHIMA, Hiroyuki INOUE, Chisato TOMODA, Minoru KIHARA, Takashi URUNO, Takuya HIGASHIYAMA, Yuuki TAKAMURA, Akihiro MIYA, Kaoru KOBAYASHI, Fumio MATSUZUKA, Akira MIYAUCHI, BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients. Endocrine Journal. ,vol. 56, pp. 89- 97 ,(2009) , 10.1507/ENDOCRJ.K08E-208
Ji-Yong Joo, Jae-Yong Park, Yeo-Hoon Yoon, Bobae Choi, Jin-Man Kim, Young Suk Jo, Minho Shong, Bon Seok Koo, None, Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective study. The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, pp. 3996- 4003 ,(2012) , 10.1210/JC.2012-2444
Hui-qin Guo, Huan Zhao, Zhi-hui Zhang, Yan-li Zhu, Ting Xiao, Qin-jing Pan, Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology: Data from Mainland China Disease Markers. ,vol. 2014, pp. 912182- 912182 ,(2014) , 10.1155/2014/912182
Kathleen C. Lee, Carol Li, Eric B. Schneider, Yongchun Wang, Helina Somervell, Matthew Krafft, Christopher B. Umbricht, Martha A. Zeiger, Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer Surgery. ,vol. 152, pp. 977- 983 ,(2012) , 10.1016/J.SURG.2012.08.019
Gisele Oler, Janete M. Cerutti, High Prevalence of BRAF Mutation in a Brazilian Cohort of Patients With Sporadic Papillary Thyroid Carcinomas Correlation With More Aggressive Phenotype and Decreased Expression of Iodide-Metabolizing Genes Cancer. ,vol. 115, pp. 972- 980 ,(2009) , 10.1002/CNCR.24118
Jorge Albores-Saavedra, Donald Earl Henson, Evan Glazer, Arnold M. Schwartz, Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype--papillary, follicular, and anaplastic: a morphological and epidemiological study. Endocrine Pathology. ,vol. 18, pp. 1- 7 ,(2007) , 10.1007/S12022-007-0002-Z