Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective study.
作者： Ji-Yong Joo , Jae-Yong Park , Yeo-Hoon Yoon , Bobae Choi , Jin-Man Kim
DOI: 10.1210/JC.2012-2444
关键词:
摘要: Context: Few reports have determined whether preoperative detection of the BRAF V600E mutation in fine-needle aspiration biopsy (FNAB) may influence determination surgical extent such as prophylactic central lymph node dissection (CLND) patients with papillary thyroid carcinoma (PTC). Objectives: Our objectives were to investigate analysis assist extent, including CLND variable clinicopathological risk factors for metastasis, PTC and clinically node-negative neck. Patients Methods: From July 2009 May 2011, we prospectively enrolled 148 neck who received a total thyroidectomy CLND. by pyrosequencing was tested on FNAB specimens. The relationships between occult metastasis or analyzed. Additionally, assessed asso...
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