The beneficial effects of estradiol on attentional processes are dependent on timing of treatment initiation following ovariectomy in middle-aged rats.

摘要: The goal of the present study was to explore effects long-term hormone deprivation on ability subsequent estrogen treatment affect attention performance 5-choice serial reaction time task (5-CSRTT). In an initial experiment assess estradiol in young adults, 2-month-old rats were trained 5-CSRTT, then ovariectomized and immediately implanted with capsules containing cholesterol (n=10) or (n=10). Then tested 5-CSRTT under baseline parameters, increased difficulty (behavior challenge condition), finally muscarinic nicotinic drug conditions. a second experiment, 10-month-old at 12 17 months age treated cholesterol, so that one group received continuous control treatment, two groups following ovariectomy (either months), delayed initiated 5 ovariectomies. At age, 5-CSRTT. Baseline comparable between estradiol- cholesterol-treated both groups. However, estradiol-treated outperformed controls when behavior challenged by shortening intertrial interval (Short ITI). same Short ITI condition, middle-aged receiving immediate beginning months, but not as well animals treatment. No differences found cholinergic These data indicate chronic for approximately 1 month 6 is able enhance performance, prolonged ovarian attenuates these beneficial findings have implications informing clinical research about importance timing duration