Splenic histology and histopathology: an update

摘要: The spleen can be a troublesome specimen for the surgical pathologist, not only because experience with range of "normal" splenic histology is limited by its rarity but also there an often frustrating discordance between patient's clinical condition and perceived findings. Patients dramatic presentation that points to pathology ("hypersplenism" or marked splenomegaly) infrequently have no discernable barely perceptible histologic abnormalities spleen. Similarly, patients whose spleens contain findings seem deviate significantly from "norm" (histiocytic proliferations, vasoformative lesions, stromal hyperplasia) may clinically detectable hematologic complaints. For most pathologists, frame reference normal histomorphology derives largely autopsy removed trauma immune thrombocytopenia. These are all settings in which pre-existing disease, status patient, therapy influence and--in cases fixation has been delayed--even ability make This review presents practical aspects development immunoarchitecture relates this pathologist's approach evaluating abnormal assists resolving such discordances. Benign conditions contrast subjects subsequent articles issue emphasized.