Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders

摘要: Spleen is a common site of extramedullary hematopoiesis. Extramedullary hematopoiesis seen in non-neoplastic conditions can occasionally be extensive and raise concerns for myeloid neoplasm. We compared the morphologic immunohistochemical features splenic hematopoietic proliferations neoplastic disorders (eg chronic myeloproliferative disorders, myelodysplastic/myeloproliferative acute leukemias) to variety reactive conditions. In all, 80 spleen specimens were reviewed. The presence each marrow-derived lineage, dysplasia results evaluated (CD34, CD117, myeloperoxidase, CD68, p53, TdT, CD42b hemoglobin). Neoplastic are characterized by trilineage with significant all cell lineages. Acute leukemia showed an increase immature forms, which highlighted immunohistochemistry. Reactive variability histologic features. Post-bone marrow transplant thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome spleens some immaturity, could simulate disorder. However, they lacked characteristic such as positivity CD34 or CD117.