Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only

作者: E Brogi , T Wu , A Namiki , J M Isner

DOI: 10.1161/01.CIR.90.2.649

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摘要: BACKGROUND Hypoxia and indirect angiogenic factors may stimulate angiogenesis via induction of endothelial cell mitogen(s). To evaluate this hypothesis, we investigated whether …

参考文章(23)
P A D'Amore, R W Thompson, Mechanisms of angiogenesis. Annual Review of Physiology. ,vol. 49, pp. 453- 464 ,(1987) , 10.1146/ANNUREV.PH.49.030187.002321
David W Leung, George Cachianes, Wun-Jing Kuang, David V Goeddel, Napoleone Ferrara, None, Vascular endothelial growth factor is a secreted angiogenic mitogen Science. ,vol. 246, pp. 1306- 1309 ,(1989) , 10.1126/SCIENCE.2479986
M Klagsbrun, P A D'Amore, Regulators of angiogenesis. Annual Review of Physiology. ,vol. 53, pp. 217- 239 ,(1991) , 10.1146/ANNUREV.PH.53.030191.001245
MS Pepper, N Ferrara, L Orci, R Montesano, None, Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro Biochemical and Biophysical Research Communications. ,vol. 189, pp. 824- 831 ,(1992) , 10.1016/0006-291X(92)92277-5
Werner Risau, Hannes Drexler, Vladimir Mironov, Anja Smits, Agneta Siegbahn, Keiko Funa, Carl-Henrik Heldin, Platelet-Derived Growth Factor is Angiogenic In Vivo Growth Factors Journal. ,vol. 7, pp. 261- 266 ,(1992) , 10.3109/08977199209046408
A. B. Roberts, M. B. Sporn, R. K. Assoian, J. M. Smith, N. S. Roche, L. M. Wakefield, U. I. Heine, L. A. Liotta, V. Falanga, J. H. Kehrl, Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 4167- 4171 ,(1986) , 10.1073/PNAS.83.12.4167
J.Geoffrey Pickering, Lawrence Weir, Kenneth Rosenfield, Joseph Stetz, Jaclynn Jekanowski, Jeffrey M. Isner, Smooth muscle cell outgrowth from human atherosclerotic plaque: Implications for the assessment of lesion biology Journal of the American College of Cardiology. ,vol. 20, pp. 1430- 1439 ,(1992) , 10.1016/0735-1097(92)90259-P
Peter Libby, Kathleen V. O'Brien, Culture of quiescent arterial smooth muscle cells in a defined serum-free medium Journal of Cellular Physiology. ,vol. 115, pp. 217- 223 ,(1983) , 10.1002/JCP.1041150217
S Kourembanas, R L Hannan, D V Faller, Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. Journal of Clinical Investigation. ,vol. 86, pp. 670- 674 ,(1990) , 10.1172/JCI114759
Piotr Chomczynski, Nicoletta Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry. ,vol. 162, pp. 156- 159 ,(1987) , 10.1016/0003-2697(87)90021-2