Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair
作者： Michael A. Slivka , Neil C. Leatherbury , Kris Kieswetter , Gabriele G. Niederauer
DOI: 10.1089/107632701753337717
关键词:
摘要: Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared mechanical properties tailored for use in articular cartilage repair. Compression testing was performed to investigate the influence of physiological conditions, manufacturing method, anisotropic due predominant fiber orientation, amounts reinforcement (0 20 wt, %), and viscoelasticity via a range strain rates. Using same modality, compared pig goat cartilage. Results showed that under conditions (aqueous, 37 degrees C) much lower than when tested ambient conditions. The method anisotropy significantly influenced properties. compressive modulus yield strength proportionally increased increasing up 20%. From 0.01 10 mm/mm/min rate, logarithmic fashion, semi-log fashion. non-reinforced most similar using but improvement stiffer could provide needed structural support vivo loads.
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