Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction

摘要: Abstract Background. The large volume of published randomized, controlled trials has led to a need for meta-analyses track therapeutic advances. Performing new meta-analysis whenever the results trial particular therapy are permits study trends in efficacy and makes it possible determine when treatment appears be significantly effective or deleterious. We describe use such procedure, cumulative meta-analysis, assess among patients with myocardial infarction. Methods. performed clinical that evaluated 15 treatments preventive measures acute Results. An example this method is its application intravenous streptokinase as thrombolytic Thirty-three evaluating were between 1959 1988. found consistent, statistically significant reduction total mortality (odds ratio, 0.74; 95...