Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.
作者： A C Rapraeger , A Friedl , A Tierney , Z Chang
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摘要: Fibroblast growth factors (FGFs) play multiple roles during development and in adult tissues as paracrine regulators of differentiation. FGFs signal through transmembrane receptor tyrosine kinases, but heparan sulfate is also required for signaling by members the FGF family. In addition, may be involved determining tissue distribution FGFs. Using biotinylated FGF-2 FGF-7 (KGF) probes, we have identified specific interactions between sulfates human tissues. Both species bind to mast cells epithelial cell membranes. Binding basement membrane source dependent specific. Although strongly binds skin most other sites examined, fails locations. However, subendothelial matrix blood vessels a papillary renal carcinoma, strong binding seen. summary, distinct affinities different were that affect factor activation local distribution. Heparan gatekeeper function either restrict or permit diffusion heparin-binding across membrane.
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