Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

摘要: Background Dendritic cells (DCs) regulate the immune response to allergens in lung; they induce either effector or regulatory T cells, which promote suppress, respectively, development of allergy. IL-10 is a potent immunosuppressive cytokine that induces type 1 (Tr1) cells. Objective To generate allergen-specific Tr1 vitro from children with Methods Monocyte-derived DCs allergy house dust mites (HDM) were generated by incubating and pulsing them Der p 2, major HDM allergen, 2 during their last days differentiation. Results 2–specific T-cell proliferation H production significantly reduced when patients activated autologous 2–pulsed had been differentiated incubated IL-10. lines hyporesponsive reactivation able suppress Conclusion presence pulsed allergen gave rise population tolerogenic induced This finding represents an important step forward prospective clinical application modulate responses.