Methods for In Vitro Generation of Human Type 1 Regulatory T Cells
作者： Silvia Gregori , Maria Grazia Roncarolo , Rosa Bacchetta
DOI: 10.1007/978-1-60761-869-0_3
关键词:
摘要: Type 1 regulatory T (Tr1) cells are adaptive that induced in the periphery upon chronic exposure to antigen (Ag) a tolerogenic environment containing interleukin (IL)-10. Tr1 Ag-specific; they produce high levels of IL-10 and TGF-β absence IL-4 suppress T-cell responses via cytokine-dependent mechanism. During last decade, several protocols have been developed generate cell lines vitro. In this chapter, we outline non-Ag- Ag-specific assays used characterize phenotype functions.
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