Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation.

摘要: BACKGROUND: Iron deficiency anemia is an important reason for blood donor deferral. We prospectively determined whether screening donors with hemoglobin (Hb) and iron indices before donation can predict subsequent deferral due to anemia. STUDY DESIGN AND METHODS: recruited premenopausal, eligible (nonanemic) female donors. Hb, ferritin, soluble transferrin receptor (sTfR), hepcidin were measured, the sTfR/(log)ferritin (sTfR-F) index was calculated. After 6 months, database reviewed had returned undergone successful recorded. RESULTS: Of donors, 59 of 261(22.6%) depleted (ferritin < 15 ng/mL). Iron-depleted donated more often in previous year, younger, lower Hb. a minimum 145 returned; these 10 (6.9%) deferred anemia. Donors who developed significantly higher sTfR sTfR-F at baseline. The area under receiver operating characteristic curve Hb as predictor 0.86, ferritin 0.88. Hb of less than 130 g/L ferritin of 10 ng/mL combined sensitivity 80% specificity 96% predicting deferral. CONCLUSION: Screening enables prediction risk would most benefit from prevention strategies.