The role of surgery in treatment of stage IV melanoma.

摘要: The prognosis for patients with melanoma has not improved over the last 30 years. So far, almost without exception, clinical trials conducted single or multiple agent chemotherapy, biological therapy (interferon-alpha, interleukin-2), and biochemotherapy have failed to demonstrate consistent survival benefit. Without effective alternate treatments, surgery must be considered primary treatment of melanoma, independent disease stage. Although is clearly favored as localized consensus opinion clinician preference become divided once progresses beyond its site. Many physicians will adopt an attitude resignation hesitancy when treating metastatic melanoma. As a result, advanced are often treated medications that produce little palliative benefit at expense significant toxicity. Numerous studies demonstrated clear durable advantages undergoing complete resection Further, surgical can immediate decrease in tumor burden minimal morbidity mortality reasonable cost.