Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila.
作者： Andrew Tomlinson , David D.L. Bowtell , Ernst Hafen , Gerald M. Rubin
DOI: 10.1016/0092-8674(87)90019-5
关键词:
摘要: The Drosophila gene sevenless encodes a putative trans-membrane receptor required for the formation of one particular cell, R7 photoreceptor, in each ommatidium compound eye. Mutations this result cell normally destined to form forming non-neuronal type instead. These observations have led proposal that protein receives at least part positional information developmental pathway. We generated antibodies specific and examined expression by light electron microscopy. is present transiently high levels 9 cells developing detectable several hours before any overt differentiation R7. mostly localized apices cells, microvilli, but also found deeper tissue where certain contact R8 cell. This finding suggests expresses ligand protein.
mendeley.com参考文章(20)
Margaret M. Perry, Further studies on the development of the eye ofDrosophila melanogaster. I. The ommatidia Journal of Morphology. ,vol. 124, pp. 227- 247 ,(1968) , 10.1002/JMOR.1051240208
Lisa Coussens, Charles Van Beveren, Douglas Smith, Ellson Chen, Richard L. Mitchell, Clare M. Isacke, Inder M. Verma, Axel Ullrich, Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus Nature. ,vol. 320, pp. 277- 280 ,(1986) , 10.1038/320277A0
Peter A. Lawrence, Sheila M. Green, Cell lineage in the developing retina of Drosophila Developmental Biology. ,vol. 71, pp. 142- 152 ,(1979) , 10.1016/0012-1606(79)90088-5
Richard M. Lebovitz, Donald F. Ready, Ommatidial development in Drosophila eye disc fragments Developmental Biology. ,vol. 117, pp. 663- 671 ,(1986) , 10.1016/0012-1606(86)90335-0
Donald F. Ready, Thomas E. Hanson, Seymour Benzer, Development of the Drosophila retina, a neurocrystalline lattice Developmental Biology. ,vol. 53, pp. 217- 240 ,(1976) , 10.1016/0012-1606(76)90225-6
A. Ullrich, J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, L. Coussens, Y.-C. Liao, M. Tsubokawa, A. Mason, P. H. Seeburg, C. Grunfeld, O. M. Rosen, J. Ramachandran, Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes Nature. ,vol. 313, pp. 756- 761 ,(1985) , 10.1038/313756A0
A. Ullrich, L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L. V. Mayes, N. Whittle, M. D. Waterfield, P. H. Seeburg, Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells Nature. ,vol. 309, pp. 418- 425 ,(1984) , 10.1038/309418A0
A. TOMLINSON, D. F. READY, Sevenless: a cell-specific homeotic mutation of the Drosophila eye. Science. ,vol. 231, pp. 400- 402 ,(1986) , 10.1126/SCIENCE.231.4736.400
Utpal Banerjee, Patricia J. Renfranz, John A. Pollock, Seymour Benzer, Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye Cell. ,vol. 49, pp. 281- 291 ,(1987) , 10.1016/0092-8674(87)90569-1
J. A. Campos-Ortega, Gerd J�rgens, Alois Hofbauer, cell clones and pattern formation: Studies onsevenless, a mutant ofDrosophila melanogaster. Wilhelm Roux's Archives of Developmental Biology. ,vol. 186, pp. 27- 50 ,(1979) , 10.1007/BF00848106