Mechanisms and factors involved in development of hypertrophic scars

摘要: Fibroblasts in granulation tissue (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle cells, such as the presence microfilament bundles expression α-smooth actin. The mechanisms leading to development myofibroblastic remain unclear. Both vivo vitro investigations suggest participation growth factors, cytokines, extracellular matrix regulation actin expression. During normal wound healing, myofibroblasts disappear when is fully re-epithelialized. In contrast, a permanent feature present fibrocontractive diseases. hypertrophic scars, these cells may represent an important element pathogenesis retraction. Different therapeutic modalities available for treatment scars cause decrease number expressing myofibroblasts. Further studies regarding cytoskeleton markers fibroblastic are needed understand scarring fibrosis.