La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering
作者： Xiao-Yuan Peng , Min Hu , Fang Liao , Fan Yang , Qin-Fei Ke
DOI: 10.1039/C8BM01498A
关键词:
摘要: Trace rare earth elements such as lanthanum (La) regulated effectively bone tissue performances; however, the underlying mechanism remains unknown. In order to accelerate defects especially in patients with osteoporosis or other metabolic diseases, we firstly constructed lanthanum-doped mesoporous calcium silicate/chitosan (La-MCS/CTS) scaffolds by freeze-drying technology. During procedure, three-dimensional macropores were produced within La-MCS/CTS using ice crystals templates, and La-MCS nanoparticles distributed on macropore walls. The hierarchically porous structures biocompatible components contributed adhesion, spreading proliferation of rat marrow-derived mesenchymal stem cells (rBMSCs), accelerated in-growth new tissues. Particularly, La3+ ions remarkably induced osteogenic differentiation rBMSCs via activation TGF signal pathway. A critical-sized calvarial-defect model further revealed that significantly promoted regeneration compared pure MCS/CTS scaffolds. conclusion, scaffold showed prominent ability osteogenesis regeneration, which its application potential for defect therapy.
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