Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
作者： Henna Heinonen , Anni Nieminen , Matti Saarela , Anne Kallioniemi , Juha Klefström
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摘要: … cancer and the role of p70S6K as a downstream mediator of PI3K/mTOR pathway, our aim was to identify PI3K/mTOR/… gene expression profiling for breast cancer cell lines that we have …
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T Brodowicz, D Kandioler, S Tomek, C Ludwig, M Rudas, R Kunstfeld, W Koestler, M Hejna, A Budinsky, C Wiltschke, C C Zielinski, Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status. British Journal of Cancer. ,vol. 85, pp. 1764- 1770 ,(2001) , 10.1054/BJOC.2001.2197
J. R. Marks, G. L. Scott, P. L. Davis, W.-L. Shaiu, J. D. Iglehart, T.-S. Hsieh, Complex response of breast epithelial cell lines to topoisomerase inhibitors. Anticancer Research. ,vol. 18, pp. 2919- 2932 ,(1998)
Matthias Simon, Tjoung-Won Park, Gertraud Köster, Ralph Mahlberg, Matthias Hackenbroch, Jan Boström, Jan Boström, Thomas Löning, Johannes Schramm, Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression. Journal of Neuro-oncology. ,vol. 55, pp. 149- 158 ,(2001) , 10.1023/A:1013863630293
Maarit Bärlund, Outi Monni, Juha Kononen, Guido Sauter, Olli-P. Kallioniemi, Anne Kallioniemi, Joachim Torhorst, Robert Cornelison, Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. Cancer Research. ,vol. 60, pp. 5340- 5344 ,(2000)
Fabrizio Loreni, George Thomas, Francesco Amaldi, Transcription inhibitors stimulate translation of 5 ' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway FEBS Journal. ,vol. 267, pp. 6594- 6601 ,(2000) , 10.1046/J.1432-1327.2000.01753.X
C. David James, Guo Jun Wu, Junqi Qian, Robert B. Jenkins, Fergus J. Couch, Xiao Yang Wang, Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer. Cancer Research. ,vol. 59, pp. 1408- 1411 ,(1999)
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Katrin Lorenz, Eva H. Lee, Mary Helen Barcellos-Hoff, Ole W. Petersen, Joe W. Gray, Mina J. Bissell, The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression Molecular Oncology. ,vol. 1, pp. 84- 96 ,(2007) , 10.1016/J.MOLONC.2007.02.004
Sathish Kumar Mungamuri, XiaoHe Yang, Ann D. Thor, Kumaravel Somasundaram, Survival Signaling by Notch1: Mammalian Target of Rapamycin (mTOR)–Dependent Inhibition of p53 Cancer Research. ,vol. 66, pp. 4715- 4724 ,(2006) , 10.1158/0008-5472.CAN-05-3830
Jacques Montagne, Mary J Stewart, Hugo Stocker, Ernst Hafen, Sara C Kozma, George Thomas, Drosophila S6 Kinase: A Regulator of Cell Size Science. ,vol. 285, pp. 2126- 2129 ,(1999) , 10.1126/SCIENCE.285.5436.2126
Yuhong Chen, Yang Zheng, David A Foster, Phospholipase D confers rapamycin resistance in human breast cancer cells Oncogene. ,vol. 22, pp. 3937- 3942 ,(2003) , 10.1038/SJ.ONC.1206565