Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.
作者： T Brodowicz , D Kandioler , S Tomek , C Ludwig , M Rudas
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摘要: Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated effect of anti-Her-2/neu on human cell lines SK-BR-3, HTB-24, HTB-25, HTB-27, HTB-128, HTB-130 HTB-131 relation p53 genotype bcl-2 status. HTB-128 cells exhibited mutant p53, whereas wild type was found HTB-27 All seven weakly expressed protein (10–20%). antibody, irrespective status, induced all 7 dose- time-dependently correlated with Her-2/neu overexpression. addition, incubation did not alter or expression. Anti-HER-2/neu negative HBL-100 HTB-132 lines. Our results indicate that within panel tested lines, antibody-induced independent from presence intact p53. © 2001 Cancer Research Compaign http://www.bjcancer.com
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