Gadolinium mesoporphyrin as an MR imaging contrast agent in the evaluation of tumors: an experimental model of VX2 carcinoma in rabbits.
作者： Tae Kyoung Kim , Byung Ihn Choi , Sun Won Park , Whal Lee , Joon Koo Han
DOI: 10.2214/AJR.175.1.1750227
关键词:
摘要: OBJECTIVE. We determined the enhancement features of experimentally induced malignant tumors on MR imaging with use gadolinium mesoporphyrin, a recently developed contrast agent that may be necrosis-specific.MATERIALS AND METHODS. VX2 carcinoma was inoculated into 24 rabbit thighs. T1-weighted contrast-enhanced IV gadopentetate dimeglumine (2-min delay) and mesoporphyrin (20-hr performed 3-4 days (n = 6), 6-7 10-11 5), 13-14 7) after implantation carcinoma. All were sectioned along same plane images, detailed imaging-histopathologic correlation performed.RESULTS. Pathologically, areas enhanced included necrotic tissue, viable tumor, inflammatory granulation hemorrhage, fibrosis. On dimeglumine-enhanced unenhanced tumor corresponded intratumoral necrosis hemorrhage.CONCLUSION. Gadolinium mesopo...
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