Localization and determination of infarct size by Gd-Mesoporphyrin enhanced MRI in dogs

摘要: Background: Accurate localization and sizing of a myocardial infarction are necessary for clinical decision making even more in research. Gd-Mesoporphyrin enhanced magnetic resonance imaging (MRI) was recently shown to specifically delineate necrosis liver tumors, renal muscle rats. In this study, we investigated technique's potential accurately larger animal species, the dog. Methods: Myocardial induced 8 dogs by ligation left anterior descending coronary artery, 4 which were reperfused after 3 hr (0.05 mmol/kg) injected intravenously 210 min onset ischemia (n = 6) or 24 2 with non-reperfused infarctions. MRI performed 10 administration Gd-Mesoporphyrin. vivo consisted EKG-triggered, respiratory gated T1-weighted spin echo segmented turboFLASH long short axis measurements. Post-mortem, measurement repeated. Infarct size determined planimetrically TTC staining ventricular slices. Results: all instances, there very close qualitative agreement between defined infarction. Quantitatively, linear regression from post-mortem infarct yielded result line identity (regression coefficient: 0.980 +/- 0.026, p<0.000001, adjusted R-2 0.964). Conclusion: We conclude that is promising tool accurate delineation