Metalloporphyrins and Functional Analogues as MRI Contrast Agents

摘要: Following the footprint of porphyrin-mediated photodynamic therapy (PDT), paramagnetic metalloporphyrins were originated as tumor seeking contrast agents (CAs) for magnetic resonance imaging (MRI). However, serial research has disproved their selectivity, identified nonviable tissues real targets, and eventually elicited new applica- tions in myocardial infarction delineation, tissue viability evaluation, ablation assessment, well first pass or dynamic perfusion MRI, multi-organ enhancement (CE), atherosclerotic plaque stem cell labeling tracking. Furthermore, nonporphyrin analogues have been developed to reduce porphyrin related toxicities. These porphy- rin compounds termed necrosis-avid (NACAs) denote major dis- covered affinity. The present review aims document evolving this particular field, discuss possible mechanisms, promote further preclinical clinical development unique promising class MRI CAs, implicate a novel stroma targeting strategy diagnosis treatment malignant benign disorders.