Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome

摘要: Abstract MicroRNAs (miRNAs) regulate posttranscriptional gene expression usually by binding to 3′-untranslated regions (3′UTRs) of target message RNAs (mRNAs). Previous studies have demonstrated that SNPs within miRNA sites could modulate miRNA–mRNA interaction affect the regulation genes and individual's diseases. So far, little is known about relationship site polymorphisms with risk metabolic syndrome (MetS) in general population. Therefore, we conducted a case–control study Chinese Han population evaluate association between MetS. 8 minor allele frequency (MAF) ≥ 0.05 were selected bioinformatics software. TaqMan ®assay was performed test genotypes MetS patients (n = 1026) normal controls (n = 1032). We found rs5750146 (adjusted odds ratio (OR) = 1.24 for GA/AA, P  = 0.023, compared GG), rs5999924 OR = 1.22 AT/TT,  = 0.038, AA) APOL6 3′UTR identified correlate total sample females. Rs11724758 OR = 0.65 AA,  = 0.002, GG) FABP2 males. Correlations rs11724758 components reveal high-density lipoprotein cholesterol (HDL-c) levels are significantly higher AA genotype carrier noncarriers, whereas triglycerides (TG) fasting plasma glucose (FG) be lower carrier. These findings indicate these three which located at predicted miRNAs contribute susceptibility