Eating disorders: from twin studies to candidate genes and beyond

摘要: Substantial effort has been put into the exploration of biological background eating disorders, through family, twin and molecular genetic studies. Family studies have shown that anorexia (AN) bulimia nervosa (BN) are strongly familial, familial etiologic factors appear to be shared by both disorders. Twin often focus on broader phenotypes or subthreshold These consistently yielded moderate substantial heritabilities. In addition, there a proliferation focused Diagnostic Statistical Manual Mental Disorders (4th ed.; DSM-IV; American Psychiatric Association, 1994) AN BN. Seven linkage regions identified in genome-wide screens. Many association performed, but no consistent between candidate gene BN reported. Larger collaborations needed examine involvement several genes pathways should designed assist work further exploring determinants endophenotypes, evaluating magnitude contribution liability measured genotypes as well environmental risk related this manner can move field forward mutually informative way.