Effects of racial and ethnic group and health literacy on responses to genomic risk information in a medically underserved population

摘要: OBJECTIVE Few studies have examined how individuals respond to genomic risk information for common, chronic diseases. This randomized study differences in responses by type of (genetic test/family history) and disease condition (diabetes/heart disease), race/ethnicity a medically underserved population. METHODS 1,057 English-speaking adults completed survey containing 1 4 vignettes (2-by-2 design). Differences dependent variables (i.e., interest receiving assessment, discussing with doctor or family, changing health habits) experimental were using chi-squared tests multivariable regression analysis. RESULTS No significant found condition. In models, Hispanics more interested assessment than Whites (OR = 1.93; p < .0001); respondents marginal 1.54; .005) limited 1.85; .009) literacy had greater those adequate literacy. Blacks 1.78; .001) family Whites. Non-Hispanic 1.45; .04) (β -0.41; -0.25; .033) intended change fewer habits Whites; was negatively associated number participants change. CONCLUSIONS Findings suggest that may affect information. Additional research could examine cognitive representations this differ across racial/ethnic groups. Health is also critical consider developing approaches communicating