Consumers' use of web-based information and their decisions about multiplex genetic susceptibility testing.

摘要: Background: Few data exist to inform concerns raised by online direct-to-consumer marketing of genetic susceptibility tests, such as those offered commercial entities like 23andme, Navigenics, and DNA Direct. The Multiplex Initiative, a population-based study healthy adults, provides the first opportunity evaluate how use Web-based decision tool that conveyed information about test influenced individuals’ decisions. Objective: To ongoing debate over whether individuals testing without involvement health care provider (eg, through testing) can make informed decisions when guided aids. Methods: Participants were 526 members large maintenance organization aged 25 40 years old who visited website. Multivariate logistic regression models tested examine association website usage with downstream Results: viewed an average 2.9 4 pages introducing multiplex test, 2.2 8 describing conditions, 3.2 15 genes. For each page viewed, participants more likely describe their decision-making easy (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.01-1.07) decide be (OR 1.08, CI 1.05-1.11). Conclusions: Healthy adults in this perceived genomic presented using evidence-based communications approaches helpful supporting both not test. Continued research is needed ensure these results generalize target groups lower literacy less Internet savvy. [J Med Res 2010;12(3):e41]