Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual cycle

摘要: Application of time series analysis to a database containing serial pregnanediol data from 113 complete ovulatory menstrual cycles contributed by 83 women proven fertility and 68 for which values were available over the period, detected first statistically significant risk in excretion all baseline was (n = 170). However, even at 99% confidence level, 22% rise observed before presumed day ovulation. Therefore, threshold value sought as better marker end fertility. A 1.4 mg per 24 h not reached 2 after pre-ovulatory estrogen peak 96% cycles. In remaining 4% it one total day. The validity this confirmed extensive studies using Ovarian Monitor where equivalent is 6.3 mumol glucuronide measurements are performed on timed urine specimens with minimum collection three hours. These follows: 1) World Health Organization study use self test home (108 cycles), 2) multicenter returning during breast feeding conducted Family International (73 women), 3) general application pregnancy achievement avoidance past ten years (over 250,000 PdG assays countries). With rare exceptions, these applicable provided correction made volume.