The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat.

摘要: The effect of feeding curcumin, capsaicin, ginger, mustard, black pepper and cumin on cholesterol bile acid metabolism was studied in rats. activity hepatic cholesterol-7 alpha-hydroxylase, the rate-limiting enzyme biosynthesis, significantly elevated curcumin (turmeric), capsaicin (red pepper), ginger mustard treated animals. comparable to controls fed Serum liver microsomal contents were higher Thus, this study has suggested that spices--turmeric, red pepper, can stimulate conversion acids, an important pathway elimination from body. However, simultaneous stimulation synthesis by spice principles--curcumin suggests there may not be any significant contribution biosynthesis hypocholesterolemic action these spices, latter solely due interference with exogenous absorption.