Antiatherogenic Effects of Ginger ( Zingiber officinale Roscoe): Scientific Observations and Ethnomedicinal Validation

作者: A.N. Prabhu , A.R. Shivashankara , R. Haniadka , P.L. Palatty , D. Prabhu

DOI: 10.1016/B978-0-12-396485-4.00267-X

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摘要: Atherosclerosis is fast becoming a leading cause for obstructive vascular diseases (like stroke, peripheral diseases, and cardiovascular diseases) major burden in both developing developed countries; therefore, its prevention preferably by using dietary constituents considered to be an attractive concept. Experimental studies performed accordance the principles of modern medicine have shown that commonly used kitchen spice ginger ( Zingiber officinale Rosc.) possesses properties contribute toward atherosclerosis complications. Scientific reduces plasma level total cholesterol, triglyceride, low-density lipoprotein cholesterol; increases high-density inhibits cholesterol biosynthesis, lipid peroxidation, aggregation lipid. Further, also enhances fibrinolytic activity antiplatelet effect which contributes reduction atheroma. This chapter addresses these aspects emphasizes on various mechanistic prevention/reduction atherosclerosis.

参考文章(42)
Khamesra R, Verma Sk, Singh J, Bordia A, Effect of ginger on platelet aggregation in man. Indian Journal of Medical Research. ,vol. 98, pp. 240- 242 ,(1993)
A Bordia, S K Verma, Ginger, fat and fibrinolysis. Indian Journal of Medical Sciences. ,vol. 55, pp. 83- 86 ,(2001)
Srinivas Nammi, Moon S. Kim, Navnath S. Gavande, George Q. Li, Basil D. Roufogalis, Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats Basic & Clinical Pharmacology & Toxicology. ,vol. 106, pp. 389- 395 ,(2009) , 10.1111/J.1742-7843.2009.00497.X
Masahiro TANABE, Yuh-Dan CHEN, Ken-ichi SAITO, Yoshihiro KANO, Cholesterol Biosynthesis Inhibitory Component from Zingiber officinale ROSCOE Chemical & Pharmaceutical Bulletin. ,vol. 41, pp. 710- 713 ,(1993) , 10.1248/CPB.41.710
Mehdi Pouramir, Mehrdad Saravi, Reza Alizadeh-Navaei, Farzad Jalali, Fatemeh Roozbeh, Ali A. Moghadamnia, Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Medical Journal. ,vol. 29, pp. 1280- 1284 ,(2008)
Bianca Fuhrman, Mira Rosenblat, Tony Hayek, Raymond Coleman, Michael Aviram, Ginger Extract Consumption Reduces Plasma Cholesterol, Inhibits LDL Oxidation and Attenuates Development of Atherosclerosis in Atherosclerotic, Apolipoprotein E-Deficient Mice Journal of Nutrition. ,vol. 130, pp. 1124- 1131 ,(2000) , 10.1093/JN/130.5.1124
JIH-HWA GUH, FENG-NIEN KO, TING-TING JONG, CHE-MING TENG, Antiplatelet effect of gingerol isolated from Zingiber officinale. Journal of Pharmacy and Pharmacology. ,vol. 47, pp. 329- 332 ,(2011) , 10.1111/J.2042-7158.1995.TB05804.X
S. Chrubasik, M.H. Pittler, B.D. Roufogalis, Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles Phytomedicine. ,vol. 12, pp. 684- 701 ,(2005) , 10.1016/J.PHYMED.2004.07.009
Ahmed Hassan El-Ghorab, Muhammad Nauman, Faqir Muhammad Anjum, Shahzad Hussain, Muhammad Nadeem, None, A comparative study on chemical composition and antioxidant activity of ginger (Zingiber officinale) and cumin (Cuminum cyminum). Journal of Agricultural and Food Chemistry. ,vol. 58, pp. 8231- 8237 ,(2010) , 10.1021/JF101202X
M. Thomson, K.K. Al-Qattan, S.M. Al-Sawan, M.A. Alnaqeeb, I. Khan, M. Ali, The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 67, pp. 475- 478 ,(2002) , 10.1054/PLEF.2002.0441