Cholesterol Biosynthesis Inhibitory Component from Zingiber officinale ROSCOE

摘要: We previously reported on the isolation and identification of (E)-8 beta,17-epoxylabd-12-ene-15,16-dial (ZT) from ginger (rhizome Zingiber officinale Roscoe, Zingiberaceae). In this paper, pharmacological effects ZT are reported. The experimental mouse hypercholesterolemia induced by Triton WR-1339 was treated after oral administration ZT. homogenated rat liver with ZT, cholesterol biosynthesis decreased. addition, same activity observed in which resected According to results general screening, no remarkable except for an inhibitory effect biosynthesis.