Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

摘要: We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia. All 12 T type had germ-line kappa lambda genes 11 heavy chain genes. In contrast, all 25 "non-T, non-B" classification, which lacked both definitive markers immunoglobulin, rearranged genes, indicating that they represent precursor cells already committed to B lineage at level. 14 yet retained light whereas reorganizations. patterns rearrangement predicted by a model proceeds from recombination were observed. Despite uniform presence only five produced mu-chain, one exceptional case gamma-chain, another lambda-chain. The do not produce may frequently possess ineffectively Included in this group be set trapped series because their ineffective rearrangements eliminated certain subsegments necessary for assemblage an effective gene. seven non-T, non-B subgroup bore HLA-DR but CALLA (the common leukemia-associated antigen) represented earliest recognizable stage precursors with Correlations here suggest entering development express rearrange before cell-associated recognized antibody BA-1, CALLA, any subsequent rearrangements.