Functional genomics and proteomics – the role of nuclear medicine

摘要: Now that the sequencing of human genome has been completed, basic challenges are finding genes, locating their coding regions and predicting functions. This will result in a new understanding biology as well design molecular structures potential novel diagnostic or drug discovery targets. The assessment gene function may be performed using tools program. These represent high-throughput methods used to evaluate changes expression many all genes an organism at same time order investigate genetic pathways for normal development disease. lead shift scientific paradigm: In pre-proteomics era, functional assignments were derived from hypothesis-driven experiments designed understand specific cellular processes. describe proteins on proteome-wide scale, thereby creating way doing cell research which results determination three-dimensional protein description networks. descriptions then hypotheses traditional physiological, biochemical pharmacological sense. evaluation genetically manipulated animals newly biomolecules require thorough physiology, biochemistry pharmacology experimental approaches involve technologies, including vivo imaging with single-photon emission tomography positron tomography. Nuclear medicine procedures applied regulation established tracers reporter such enzymes, receptors, antigens transporters. Pharmacogenomics identify surrogate markers therapy monitoring imaging. Also, distribution studies therapeutic needed, least during preclinical stages development. Finally, developed by bioengineering isotope-based diagnosis treatment