Palladium-catalyzed allylation of trifluoromethylated ketene aminoacetals
作者： Wengui Wang , Feng Huan , Yan Sun , Jin Fang , Xiu-Ying Liu
DOI: 10.1016/J.JFLUCHEM.2014.10.002
关键词:
摘要: Abstract A new development in the palladium-catalyzed allylation reaction of trifluoromethylated ketene aminoacetals was reported. These nucleophilic reagents were prepared by adding aminoalcohols to methyl 3,3,3-trifluoro-2-trifluoromethylpropanoate. The asymmetric version investigated using chiral oxazolidine-based starting materials or palladium catalysts. Asymmetric allylic alkylation carried out with up 74% ee a catalyst. However, no improvement observed double stereodifferentiation. results provided novel access for all-carbon quaternary carbon centers.
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