Formation of Quaternary Carbon Center with a Trifluoromethyl Group Using a Pd-Catalyzed Allylation Reaction
作者： Kazuyuki Sato , Yu Takiguchi , Yosuke Yoshizawa , Kayoko Iwase , Yoshie Shimizu
DOI: 10.1248/CPB.55.1593
关键词: Fluorine 、 Group (periodic table) 、 Palladium catalyst 、 Organic chemistry 、 Chemical synthesis 、 Chemistry 、 Carbon 、 Trifluoromethyl 、 Quaternary carbon 、 Catalysis
摘要: Synthesis of compounds with quaternary carbons is one the most attractive reactions in synthetic chemistry. However, there are only a few reports on synthesis fluoroalkyl group at carbon center. Recently, we reported α-trifluoromethylated ketones by reaction α,β-unsaturated CF3-I using Rh catalyst. When and allyl carbonates were treated Pd catalyst, allylation proceeded smoothly trifluoromethylated to give desired center good excellent yields.
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