Neoadjuvant chemotherapy or chemoradiotherapy in head and neck cancer.

摘要: The multidisciplinary approach to treating squamous cell carcinoma of the head and neck is complex evolving. Chemotherapy increasingly being incorporated into treatment neck. Previously, radiotherapy following surgery was standard loco regionally advanced resectable disease. Data from randomized trials have confirmed benefits concurrent chemo in adjuvant setting. Chemo also recommended for unresectable Advanced regional disease most frequent clinical situation Head Neck cancer. care clinicians a with concomitant chemotherapy plus (CRT). However, retrospective studies shown that patients treated CRT there relative increase systemic relapse due lack control. For this reason renewed interest has appeared incorporation induction locally Cancer. Furthermore new combination regimens taxanes be more active than classical cisplatin 5-fluorouracil regimen. Novel targeted agents, such as epidermal growth factor receptor antagonists, are showing promise both recurrent/metastatic