Thymidylate synthase gene amplification predicts pemetrexed resistance in patients with advanced non-small cell lung cancer
作者： S. Hashimoto , T. Shimizu , Y. Nakagawa , N. Takahashi
DOI: 10.1007/S12094-015-1359-Y
关键词:
摘要: Background Thymidylate synthase (TYMS) expression in lung cancer tissue affects the therapeutic efficacy of pemetrexed (PMT). TYMS protein is primarily assessed using immunohistochemistry (IHC), but this method not suitable for accurate quantitative analysis. It known whether analysis gene copy number fluorescence situ hybridization (FISH) a useful assessment expression.
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