Wistar-Kyoto and spontaneously hypertensive rat blood pressure after embryo transfer into different wombs and cross-suckling.
作者： Jong Y Lee , Silvia H Azar
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摘要: Blood pressure (BP) varies based on genetic and environmental factors. To test influences body weight (BW) BP, one-cell homozygous embryos were transferred into spontaneously hypertensive (SHR, pup:shr) or (Wistar-Kyoto normotensive [WKY], pup:wky) rats' oviducts (embryos: s,w; oviduct-uterine: S,W), cross-suckled at birth (nurses S,W) weaned to normal diets day-21. BP day-120 was measured by radiotelemetry analyzed methods of linear least square rhythmometry analysis variance. Genetics dominantly affected shr causing it be significantly higher (24.6 ± 1.8 in sS versus 21.8 1.7 mmHg wW, P < 0.005), (198 0.5 sSS 127 0.2 wWW, 0.001), with lower BW than those wky (5.3 5.7 g birth, 332 5 404 6 day-120, both 0.001). Surprisingly, uterine-suckling milieus lowered 178 0.5, 147 0.6, 179 sSW, sWS, sWW, respectively, all 0.01). slightly elevated when wky-genetics implanted the S-uterine 4 (wSW, 0.05), whereas implanting W-uterine environment (sWS) 51 (P In summary, shr-strain showed provided an WKY-uterine and/or WKY-nursing mothers, indicating that can modify influences; yet MESORs (rhythm-adjusted 24-h mean: midline estimating statistic rhythm) WKY environments remained above encountered wky-donors.
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