Ambulatory Blood Pressure Parameters and Heart Failure With Reduced or Preserved Ejection Fraction in Elderly Treated Hypertensive Patients.

摘要: BACKGROUND The association between ambulatory blood pressure (BP) and future risk of heart failure (HF) is unclear. We investigated the BP parameters HF with reduced ejection fraction (HFREF) or preserved (HFPEF) in elderly treated hypertensive patients. METHODS occurrence HFREF HFPEF was evaluated 1,191 patients who underwent clinical instrumental evaluation, including monitoring to evaluate daytime, nighttime, 24-hour BP, dipping status, morning surge (MS) BP. RESULTS During follow-up (9.1±4.9 years, range 0.4-20 years), 123 developed HF, whom 56 had 67 HFPEF. After adjustment for other covariates, Cox regression analysis showed that systolic but not clinic independently associated both (hazard ratio (HR): 1.36, 95% confidence interval (CI): 1.14-1.63, per 10mm Hg increment) (HR: 1.35, CI: 1.13-1.61, increment); moreover, high MS (>23mm Hg) dippers 2.27, 1.00-5.15) nondipping 2.78, 1.38-5.63). CONCLUSIONS In patients, HFPEF, whereas