The coming era of quadrivalent human influenza vaccines: who will benefit?

摘要: Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These are designed to protect people currently circulating Since late 1970s, this has required use a trivalent vaccine consisting two A viruses one B virus. However, since early 2000s, second lineage regularly circulated in many countries that is quite distinct, only low levels cross between lineages. Due difficulties determining which will circulate, matching be administered some 6–9 months later, there been an increasing interest development quadrivalent vaccines, containing representing both Development rapid we now on cusp new generation becoming available. This paper discusses issues rationale behind welcome who likely benefit most.