Molecular Arrangement for Physiological Action of Glutamic Acid and γ-Aminobutyric Acid

摘要: On combination of the amino group glutamate or γ-aminobutyric acid (GABA) with a receptor site, RN, steric influence α-carboxyl γ-hydrogen on adjacent carbon directs that this site in separate from surrounding protein structures. In manner space may be created membrane which measures 5.70–6.30 A case and 3.70–4.50 A for GABA. These values are good agreement diameter hydrated sodium ions (4.80–5.12 A) chloride (3.32–3.86 A). A selective increase permeability towards causes, respectively, excitation inhibition neurons. The pharmacological action certain ω-amino acids therefore associated conformational change membrane, required to accommodate space-filling configuration around carbon, nitrogen. order substituent exclusively dimensions formed, f...