Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum.

摘要: Water or aqueous ethanol extract of O. sanctum was given ip, either as a single dose multiple doses, before whole-body exposure to 11 Gy(LD100/30) 60Co gamma radiation in albino mice. The water more effective and less toxic than the extract. An optimum ip 50 mg/kg (< 1/100 LD50) extract, at 10 mg/kg/day for 5 consecutive days, gave maximum survival. Increasing per treatment number treatments did not increase protection. Intraperitoneal administration best protection (70% survival). Other routes (im, iv po) were produced 37-47% (ip) modifying factor 1.28. Since may contain chemical compounds, it is possible attribute observed any particular compound present.