Does Growth Hormone Therapy in Conjunction With Resistance Exercise Increase Muscle Force Production and Muscle Mass in Men and Women Aged 60 Years or Older

摘要: Advancing age is associated with a reduction in skeletal muscle protein and force production, syndrome referred to as sarcopenia . This process occurs during normal aging, but it accelerated by physical inactivity degenerative or other disease conditions.1 Decreased mass production are an increased risk of falling2 and, therefore, for hip fracture.3 Reduced aging can also result disability frailty1 loss independent function,4 contributes escalating health care costs.5 Our understanding the mechanisms responsible limited. The most obvious intervention exercise, feasibility effectiveness exercise this population still under investigation. Pharmacological nutritional interventions have been proposed,6–8 preliminary evidence not encouraging.6–15 Efficacious elderly people need enhance both production. The biological consequences advancing progressive decline activity contribute sarcopenia. Exercise, especially resistance training, has potential improve overall fitness quality life. physiological functional benefits activity, even into ninth decade life, reported.16 Thus, human maintains ability respond to, adapt favorably exercise-induced increases contractile throughout life span. age, however, may be somewhat limited processes. For example, circulating concentrations pulsatile release patterns several hormones that regulate metabolism reduced age.7–9,12,17–21 By virtue their anabolic actions on body proteins, low serum growth hormone …