Genetic variants in the Hippo pathway predict biochemical recurrence after radical prostatectomy for localized prostate cancer

摘要: While localized prostate cancer is potentially curative, many patients still show biochemical recurrence (BCR) after curative treatments such as radical prostatectomy (RP). The Hippo pathway has recently been shown to be an evolutionarily conserved regulator of tissue growth, and its perturbation can trigger tumorigenesis. We hypothesize that genetic variants the may influence clinical outcomes in patients. genotyped 53 tagging single-nucleotide polymorphisms (SNPs) from seven core genes 246 treated with RP. Kaplan-Meier analysis Cox proportional hazard models were utilized identify significant SNPs correlated BCR. For replication, five associated independent cohort 212 After adjusting for known clinicopathologic factors, association between STK3 rs7827435 BCR (P = 0.018) was replicated second stage 0.026; Pcombined 0.001). Additional integrated silico provided evidence affects expression, which turn significantly tumor aggressiveness patient prognosis. In conclusion, contribute variable cancer, discovery these biomarkers provides a molecular approach prognostic risk assessment.